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While ROS play essential signaling roles and help regulate cellular redox status, their over-accumulation disrupts cellular integrity, leading to lipid peroxidation, protein degradation, nucleic acid damage, and ultimately cell death

Tesamorelin GH-axis analog studied in visceral adiposity and lipid metabolism research

Thus, high-dose liraglutide (Saxenda) was approved for the treatment of obesity by the US Food and Drug Administration, which became the most widely prescribed anti-obesity drug in 2020 (Neeland et al

They identified the autophagy protein ATG4 as a sensor of H 2 O 2 during starvation

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