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Because GHRH analogs and ghrelin mimetics act on different receptors, research has examined whether combining the two produces a larger, more synchronized growth hormone pulse than either route alone, as discussed in research on growth hormone secretagogues
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Indole can upregulate the expression of TJ protein mucin and anti-inflammatory factor protein IL-10 in IECs, and downregulate expression of the pro-inflammatory factor IL-8 (117, 118)
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However, the mechanism underlying exendin-4s effect on the circulating adiponectin level was unclear before this study
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