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Initial self-management strategies: Continue normal activities as much as possible NICE guideline NG59 emphasises that bed rest is not beneficial for non-specific low back pain Apply heat or cold packs to the affected area for symptomatic relief Consider appropriate pain relief NICE recommends oral NSAIDs (such as ibuprofen) at the lowest effective dose for the shortest possible time

These changes were considered mild and not dangerous in most cases

38 FXR modulates bile acid synthesis, reduces uptake, and aids their secretion into bile

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Observational studies suggest that moderate-intensity exercise reduces AF burden and improves quality of life, alongside the broader cardiovascular benefits