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Since the participants were discouraged from starting symptomatic therapy during the 52-week, Part 1, double-blind, placebo-controlled period unless deemed clinically essential, most participants experienced motor worsening before starting symptomatic therapy, which may not be replicable in future clinical trials with different study designs or population characteristics

Semaglutide starts at 0.25 mg weekly for one month, with a maximum of 2.4 mg once a week

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This provides compelling evidence that GLP-1RAs could be a potential target for SA treatment