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The pre-specified primary efficacy analyses included data from study 1 and pooled data from studies 2 and 3, regardless of glycemic rescue or treatment discontinuation
Semaglutide, taken weekly, offers greater weight loss and blood-sugar improvement but can trigger stronger GI symptoms during dose escalation
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Nevertheless, it is crucial to consider the potential adverse effects of weight fluctuation after discontinuing these medications, particularly the increased risk of cardiovascular and all-cause mortality in patients with obesity or overweight
Redox mobility shift assays For the redox mobility shift assays, proteins were purified, reduced and oxidized as described above
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