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The pathogenesis of NAFLD, schematically represented in Figure 2, is multifactorial and multiple mechanisms have been proposed to explain the process of excessive liver lipid accumulation, with the subsequent possible inflammation and fibrosis (36)

Complement Ther Med (2022) 66:102819

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GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner

OS negatively affects cell function mostly through the release of highly reactive oxygen species (ROS) within the cell environment(Bjrklund, Meguid, et al., 2020