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Sound mechanistic evidence supports the need for further research on the GLP1-RAs/SGLT2is combinations ability to modify specific risk outcomes, such as cardiovascular risk and the progression of diabetic kidney disease

To determine whether the signals share the same causal variant, we applied co-localization analysis 17 and found that the signals co-localize with high probability (BMI % versus nausea, H4 = 96.6%