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A companion mechanistic paper, Chang et al., Molecules 2014, found that the peptide up-regulated growth-hormone-receptor expression in tendon fibroblasts at both mRNA and protein levels, potentially sensitising these cells to growth hormone during repair
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Problems with intrinsic factor binding to ileal receptors in the diseased tissue leads to B12 deficiency
Many of the studies had small sample size and assessed only short-term outcomes
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