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This does not mean weight regain is inevitable or total, but it does reflect an important biological reality: GLP-1 medications work in part by suppressing appetite and slowing gastric emptying, and when the medication stops, those effects stop too

Both peptides have been shown to boost natural T production and have a favorable effect on fertility

Tirzepatide's dual GIP/GLP-1 mechanism makes it distinct from pure GLP-1 agonists like semaglutide or liraglutide

Both medications are very effective at controlling blood sugar levels and aiding in weight loss, with retatrutide showing a small advantage in trials, but semaglutide has more long-term data as its already been FDA-approved

For instance, an older person or someone who is overweight may need to take a larger Ipamorelin dose