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Clinical Evidence and Expectations The STEP trials, which evaluated the efficacy of semaglutide, demonstrated that weight loss and appetite suppression are dose-dependent
The reasoning: Dose increases often bring temporary side effects - Your body needs time to adjust to higher medication levels Thigh injections showed lower GI side effect rates - Using this site during the adjustment period may ease the transition You can always switch back - Once you know how your body handles the new dose, return to your preferred site if you wish Try thigh injections for at least the first week after stepping up (say, from 5mg to 7.5mg)
For instance, when peripheral tissues become inflamed, the related signals might be transmitted to the brain through these receptors on the neurons, and the brain could then respond to these signals via neural pathways, thus regulating the level of peripheral inflammation
Now, another contender might be emerging to join that list
(Basel) 16 (6), 836
