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Consider Generic Alternatives If Coverage Is Denied Lower-cost alternatives to tirzepatide (Zepbound) for weight loss include oral weight loss medications such as Xenical (orlistat), Contrave (bupropion/naltrexone), and Qsymia (phentermine/topiramate)

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus (under the brand name Ozempic) and chronic weight management (as Wegovy)

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Grey-market sellers package the three together because the audience is overlapping: people who want to lose fat and build muscle quickly, and who are willing to step outside licensed medicine to do it

Practical levers that can help: bring imaging or elastography results (a FibroScan showing increased liver stiffness, or an MRI showing elevated liver fat) to appointments