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People with a prior history of gastrointestinal problems and aged individuals are more likely to suffer from intense stomach cramps and severe diarrhoea after taking high doses of vitamin B. Most people are able to get enough vitamin B12 from their diets, however, occasionally when running low, supplements or B12 injections may be recommended

International Journal of Toxicology , 36(3_suppl), 5S-30S

Lower purity products may contain synthesis byproducts, degradation products, or contaminants that reduce effectiveness or introduce safety concerns