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While true allergies to methylcobalamin are exceptionally rare, any documented hypersensitivity to vitamin B12 preparations would contraindicate the use of this combination product

[108] However, high-dose or prolonged maternal corticosteroid therapy could potentially affect nursing infants

On the other hand, their pleiotropic actions, frequent involvement of the central nervous system, and context-dependent effects have historically rendered them unattractive as therapeutic targets

Studies in intestinal anastomosis healing, fistula research, and gastric protection models have all incorporated the combination as a multi-mechanism research tool