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Quality control requirements for peptide manufacturing are typically more demanding than for small molecules, requiring sophisticated analytical methods and expertise

For instance, the narrow therapeutic index of colchicine necessitates cautious dosing to prevent toxicity, while uricase therapies (e.g., pegloticase) are challenged by immunogenicity and instability (Yang Y

In db/db mice and HG-treated TECs, ectonucleoside triphosphate diphosphohydrolase 5 overexpression inhibited apoptosis to preserve TECs via regulating the protein N-glycosylation rate in ER (83)

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Poe and Corn, 2020)