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GSH synthesis and metabolism in the brain The brain has the capacity to synthesize GSH de novo from the precursors cysteine, glutamate, and glycine, as well as recycle GSH through the glutathione reductase (GR) and glutathione peroxidase (GPx) systems

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Clinical trials have shown that semaglutide and liraglutide are generally well tolerated, with gastrointestinal disorders being the most commonly reported AEs, including nausea, diarrhea, vomiting, and constipation, leading to dose reduction or temporary treatment interruption in 12.5% of study participants [40,41,42]