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By activating GLP-1 receptors in the hypothalamus and brainstem, these analogs promote satiety, leading to reduced food intake and weight loss ( Studies as Network Meta-analysis and clinical trials have shown that GLP1-RA can achieve a statistically significant decrease in HbA1C compared to placebo, as well as a weight reduction ranging between 1.3 and 8.65 kg ( With regard to cardioprotection, several mechanisms have been proposed

This therapy increases fetal Hb production by targeting BCL11A erythroid-specific enhancers to reactivate the expression of gamma-globin that makes up fetal Hb (Canver, 2015)

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