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Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007

Seeing the rapid effects motivates patients to stick to their recommended protocol

doi: 10.1182/blood.V69.2.401.401 44 SiraskarB.BallalA.BobbalaD.FllerM.LangF

Overall, despite an extensive body of evidence, whether TMAO is a risk factor, mediator, or bystander in the arrhythmia process remains largely unknown

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