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GLP-1 agonism, as many researchers are now familiar with, leads to glucose-dependent insulin secretion, slowed gastric emptying, and appetite suppression

Kidney problems - GLP-1 medications may affect kidney function, particularly in patients with pre-existing conditions

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Over the past decade, strong associations have been shown between prediabetes and risk for cardiovascular diseases, chronic kidney disease, early-onset dementia, and some cancers, such as colorectal, breast, and pancreatic cancer suggesting that prediabetes is a disease with broader implications on health

In another study, a GLP-1 receptor distinct from the classical pancreatic-type receptor was found on MC3T3-E1 cells (102)