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Strengths of the present meta-analysis are the inclusion of all CVOTs published by 10 December 2021, the very large number of participants, the high quality of the trials which minimizes the risk of bias, and the absence of significant heterogeneity in most analyses, which ranged from absent to low or moderate

Given this, the length of the needle is somewhat optional

Switching from Dulaglutide or Liraglutide to Semaglutide did not lead to a significant impact on HbA1c levels

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