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Treatment with GLP-1RAs can reduce monocyte/macrophage accumulation in the arterial wall by inhibiting the adhesion of monocytes to activated endothelium from the arteries of C57BL/6 mice as well as in ApoE -/- mice [64]

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It has yet to be determined how such a labile molecule as LTA 4 is transferred from 5-LOX to LTA4H and how the metabolite LTB 4 is transported to the plasma membrane for export, but it is presumed to be protected in a hydrophobic pocket in a protein such as albumin

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