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The GLP-1 receptor is expressed in all these subcortical target regions and also in cortical and hippocampal regions that do not get axonal input from the GLP-1 neurons in the hindbrain (Randolph et al., 2024)
Additionally, combined with metformin, medication such as Topiramate, Zonisamide, and Valproic Acid may increase the risk of lactic acidosis
[1] [3] Zepbound is not approved for use in pediatric patients, and should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus
( H ) Representative Western blots and quantification of -MSH (normalized to -actin) in the LV samples of sham-operated and Ang II-infused (4 weeks) mice
