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They help burn fat without dropping muscle

Many insurance plans require structured weight loss documentation for: Using structured tools like this calculator supports accurate care planning but does not replace official medical documentation or provider records

This systematic review was designed primarily as a signal-detection and evidence-mapping exercise, given the predominance of non-randomised and non-comparative data in this area

Its multifaceted nature and relatively low-risk profile make it a compelling candidate for therapeutic intervention across several medical contexts

Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone