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For instance, in SUSTAIN-7, semaglutide 0.5 mg and 1.0 mg were compared to dulaglutide 0.75 mg and 1.5 mg: semaglutide resulted in significantly greater A1c reduction (1.5% vs 1.1% at highest doses) ( [6] )
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Additionally, reduced mechanical loading on bones due to lower body weight can decrease the stimulus for bone formation
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