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In the labels placebo-controlled trials, the majority of reports of nausea, vomiting, and diarrhea occurred during dose escalation
While several CVOTs were performed with injectable GLP-1 RAs [46], the recent SOUL trial assessed the use of oral semaglutide, which was associated with a significantly lower risk of MACE than a placebo, without an increase in the incidence of serious adverse events, in patients with T2D and atherosclerotic cardiovascular disease (ASCVD), CKD, or both [71]
Retrieved from Fuchs FD, & Whelton PK
Puerarin attenuates diabetic kidney injury through the suppression of Nox4 expression in podocytes