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Although it has been argued that aspirin was replaced by ibuprofen rather than APAP in the US in the early 1980s [32], this is contradicted by available data demonstrating that APAP was the drug of choice in the US when the pediatric use of aspirin was dramatically reduced [29,30], Furthermore, as pointed out by Saugstad [33], ibuprofen was not approved as a prescription drug for children in the US until 1989, more than 30 years after a formulation of APAP was first marketed for children
Lash LH, Putt DA, Matherly LH
Rizzi A, Crivellato E, Benagiano V, et al
Kumar A, Mittal R
T., Neuhaus, I
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