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ALA may rescue chemotherapy-induced mitochondrial toxicity to exert neuroprotective effects, but because of the differences in its in vivo experimental findings, future studies of ALA as a potential prevention of CIPN should not be ignored, while other exogenous antioxidant supplements, such as mineral elements, phytochemicals (curcumin and hesperidin), nutritional antioxidants, cytoprotectants and synthetic compounds, have very promising results in basic research

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