Increase in rat brain glutathione following intracerebroventricular administration of -glutamylcysteine
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This enzyme is involved in the conversion of the amino acid homocysteine into methionine which is, in turn, required for DNA methylation
But keep in mind, at that time, sixty years ago, maybe the world population was three billion, now we are eight billion population
An additional open question is whether propagating ferroptotic injury contains reversible intermediate states before reaching tissue-scale collapse or whether spread proceeds as a strictly irreversible process once initiated