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10.1006/bbrc.1995.1287 6 DeFronzoR
Effects on the Brain and Circadian Rhythm GLP-1 receptors are present in parts of the brain that regulate: Sleep-wake cycles Hormone release Stress response Energy balance When semaglutide activates these pathways, the body may temporarily adjust its sleep rhythm
Patients should follow a systematic rotation pattern and maintain a written log to track application sites and prevent skin complications
These can often be controlled with proper dosing and nutrition
Wadden, T
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