reduced glutathione function antioxidant system. a Schematics for the reduction of the transport of amino acids glutathione reduced brain function Increasing

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doi: 10.3390/v12010066 59 Otulak-KozieK.KozieE.PrzewodowskiW.CiackaK.PrzewodowskaA

Although to our knowledge, there is no direct evidence of crosstalk between the GDH pathway and the GABA shunt, we speculate that the GDH pathway may interfere with the decarboxylating step of the GABA shunt by controlling the available glutamate via the action of Gdh1, Gdh2 and Gdh3 proteins under specific conditions

It activates AMPK signaling (the same pathway activated by exercise and caloric restriction), improves insulin sensitivity, enhances glucose uptake by muscle tissue, and supports mitochondrial biogenesis

These include neurological problems, worsening anemia, and long-term health risks