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Constipation may also predispose bacteria to reach excessive populations, particularly Lactobacillus species that can execute tyrosine decarboxylation, L-DOPA by converting it into dopamine in the gut hence limiting its release into the bloodstream and causing motor fluctuations (Menozzi and Schapira, 2024)

Recommended Dosage Guidelines Starting Dosage: The typical starting dosage is 0.25 mg once weekly

Sharma et al., 2024a)

These effects are associated with the drug's mechanism of action on the gastrointestinal tract