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Moreover, it appears that it is the membrane-bound form of the enzyme, on sites such as the luminal surface of capillary endothelial cells, which is more important for GLP-1 degradation than the circulating (soluble) enzyme (74, 75), questioning the relevance of any association between the plasma activity per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity

So while you probably won't do any harm by swapping your normal cup of joe for a mug of mushroom coffee (and you don't mind paying extra for it), you'd be better off serving a side of shiitakes alongside your morning eggs and cup of java