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When gain-of-function LRRK2 mutants are anchored to mitochondria, it phosphorylates and traps Rab10 nearby (Gomez et al., 2019), causing decreased interaction of Rab10 with OPTN (optineurin), which is an autophagy receptor, therefore impairing mitophagy (Wauters et al., 2020)
Furthermore, liraglutide inhibits the expression levels of TNF--mediated NF-B activation in podocytes (Ye et al., 2019)
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Mockridge JW et al
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