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In addition to vasoprotection, oral administration of quercetin-3- O -gentiobiose (2575 mg/kg) once daily for two weeks considerably improved the endurance capability of rats against fatigue, decreased serum blood urea nitrogen (BUN) and lactic acid levels, enhanced the activities of antioxidant enzymes (SOD, glutathione peroxidase) and attenuated inflammatory cytokine levels (MCP-1, IL-6 and TNF-)
Boca Raton, FL: CRC Press, Taylor & Francis Group (2015)
Given the complexity of the disease, it is therefore not surprising that dissecting cause and effect is not a simple matter
This is especially true for glutathione, which has poor oral bioavailability
