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WangCChenCWangJGuoXDengYCLiuLet al
Fasting blood panel hormones (thyroid, cortisol, leptin, reproductive hormones), iron, micronutrients, and metabolic markers
The implications are significant: these results raise the possibility that semaglutide may have insufficient central target engagement at the doses used, that the pharmacodynamic effect on AD-relevant pathways may be inadequate, or that targeting metabolic and inflammatory pathways may represent a fundamental limitation when applied to established amyloid-driven Alzheimers disease
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