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Nature 600, 197199
Previous in vitro studies demonstrated that reduced GSH levels in tumor cells promoted cell death, while elevated levels inhibited cell death [18]
Once complexed with Cu(II), the peptide backbone rearranges into a specific square-planar coordination around the copper ion, with donor atoms from the glycine amino terminus, the deprotonated amide nitrogen, the histidine imidazole, and a fourth position (carboxylate or water depending on pH)
Nrf 2, a guardian of healthspan and gatekeeper of species longevity
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