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The medication has a half-life of approximately one week, meaning most of the drug is cleared from your system in about five weeks (approximately five half-lives) after your last dose

International Journal of Dermatology , 64(6), 992-1004

A clinical trial of sitagliptin in a small sample of patients with impaired glucose tolerance and mild T2DM found significant reductions in carotid intimal thickness in sitagliptin compared with diet control alone [122]

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, et al

however, when the stress exceeds their yield stress, the materials flow and the observed viscosity drops dramatically (Figure 2B and C)