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Butler, A., Hoffman, P., Smibert, P., Papalexi, E
Fosphenytoin is dosed in terms of the equivalent phenytoin dose (phenytoin equivalents or PE)
At the 12mg dose, retatrutide reduced HbA1c by 2.2 percentage points over 36 weeks while simultaneously producing 16.9% body weight reduction a dual glycemic and metabolic benefit not observed at comparable levels with single or dual agonists
Importantly, it does not significantly stimulate ACTH, cortisol, or prolactin release at physiological doses (PMID: 9849822)
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