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doi: 10.3389/fnmol.2023.1238453 115 GudiVkuljecJYildizFrichertKSkripuletzTMoharregh-KhiabaniDet al

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These studies suggest that the loss of antioxidant defense is an early biochemical event rather than a late-stage consequence of neuronal death

It is that the hormonal environment governing how fat is stored and mobilized has changed, and no amount of caloric restriction directly addresses GH pulse frequency