converting from semaglutide to tirzepatide Dose-equivalence reference based on pivotal GLP-1/dual-agonist trials: SURMOUNT-1 (tirzepatide/Zepbound, 72 weeks) STEP-1 (subcutaneous semaglutide/Wegovy, 68 weeks) OASIS-4 (oral semaglutide/Wegovy, 64 weeks). For educational comparison only—these are semaglutide and tirzepatide equivalent doses

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2c and Supplementary Table 8), 105156 weeks ( n = 3, one trial each for liraglutide 31 , orlistat 32 and semaglutide 17 reporting a placebo-subtracted TBWL of 4.2%, 3.0% and 8.7%, respectively) and more than 156 weeks (one trial with orlistat 32 reporting a 3% TBWL compared to placebo and one subgroup analysis of a trial with tirzepatide 33 reporting 19.3% TBWL)

When recovery improves, people may be able to: Exercise more frequently Return to workouts sooner Increase overall activity levels Stay consistent with training Over time, these factors can contribute to weight loss and improvements in body composition

In the UK, semaglutide is available as Ozempic (for diabetes) and Wegovy (for weight management), while liraglutide is available as Victoza (for diabetes) and Saxenda (for weight management)

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