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It can make a big difference. (P1, male, obesity)

This tri-agonist model allows researchers to dissect how hormonal signals converge to influence glucose homeostasis, insulin action, and fat storage, providing deeper insights than single-pathway agents

Lancet Diabetes Endocrinol 13(6):482493 Stefanakis K, Kokkorakis M, Mantzoros CS (2024) The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation

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