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4 Discussion Dysregulated estrogen signaling is a critical factor contributing to anti-estrogen resistance and bone metastasis in breast cancer ( Recent studies have shown that the escape of cancer cells from both apoptosis and ferroptosis are associated with treatment failure in cancer patients ( Herein, it was shown that FXR1 expression was elevated in ER+ breast cancer and further increased in anti-estrogen resistant breast cancer cells

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GLP-1 medications mimic the natural action of the gut hormone glucagon-like peptide-1 (GLP-1), which regulates blood sugar levels and appetite