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Health experts have cautioned against use of the drugs, citing a lack of clinical trials for humans and the unknown long-term effects of the substances

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In the US it was previously made by compounding pharmacies, then placed on the FDA's Category 2 bulk substances list in 2023 over safety concerns

Proc Natl Acad Sci (2020) 117:23028

When to Seek Medical Attention While mild ear pain during chewing can sometimes resolve on its own, certain signs indicate the need for professional evaluation