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Retatrutide , based on Phase 2 data, shares adverse effects with other GLP-1-based therapies

Stopping GLP-1 drugs can quickly erase cardiovascular benefits Even brief interruption tied to change in risk of heart attack, stroke and death Sara Moser and Alaska Adams / WashU Medicine Following a rapid increase in popularity of GLP-1 drugs for diabetes and weight loss, such as semaglutide and tirzepatide, approximately one in eight U.S

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Specific variants in genes like GIPR, FTO, and MC4R may influence baseline peptide sensitivity and medication efficacy