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Post-Inflammatory Hyperpigmentation Risk The most significant concern, particularly with microneedling combination protocols, is post-inflammatory hyperpigmentation (PIH)
Increased advanced glycosylation end products in a high-glucose environment also affects osteoblast differentiation and function
Similarly, exposure to heavy metals such as lead, cadmium, and mercury can disrupt redox balance by catalyzing the production of ROS through Fenton-like reactions or by depleting cellular antioxidants [40]
10.3389/fimmu.2021.720363 Front Immunol
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