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If the increase from 0.5mg to 1.0mg triggers significant nausea, stepping to 0.75mg first can ease the transition
If your symptoms started shortly after beginning treatment or during a dose change, its likely linked
Approval of the higher dose was based on the findings of the STEP UP clinical trial, results of which were published in November 2025
Retatrutide has shown strong weight loss results in early research, with people losing an average of 28.7% of their body weight over roughly 68 weeks at the highest studied dose
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