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The primary adverse reaction to EX is nausea, suggesting that nausea may be the primary mechanism of weight loss (52)
When they are being stimulated, they activate NF-kB which increases the production of pro-inflammatory cytokines such as IL-6 and TNF-a
Shahid, R
The earliest patent expiration date for a drug product related to Ozempic is May 23, 2024
Any future GLP-1 patch formulations would need to demonstrate similar therapeutic benefits across these indications through rigorous clinical trials before receiving regulatory approval from the MHRA and EMA
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