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Mechanism of Action Comparison# Retatrutide# Retatrutide (LY3437943) is a 39-amino acid synthetic peptide that simultaneously activates three metabolically important receptors: GLP-1 receptor : Enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite through hypothalamic and brainstem signaling GIP receptor : Potentiates insulin secretion, may improve beta-cell survival, and contributes to adipose tissue metabolism and central appetite regulation Glucagon receptor : Increases hepatic energy expenditure, promotes fatty acid oxidation in the liver, stimulates thermogenesis in brown adipose tissue, and enhances lipolysis The glucagon receptor component is the defining innovation

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