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The administration of pharmacologic quantities of GLP-1 analogs result in plasma activities that are 5- to 7-fold higher than physiologic levels
However, there are major differences between these medications, including how they affect your body and how long you should use them
This is important because it indicates that any increase in systemic GLP-1 levels (for example through medication) could potentially influence the amount that reaches the joint. Tue Wenzel Kragstrup, MD, PhD The next step (in this research) is to find out whether GLP-1-based drugs reach the joints in high enough concentrations to have biological effects there, Kragstrup continued
More recently, Nishiyama Y et al
Eli Lilly, the manufacturer of the injectable weight-loss medication Zepbound, has its own oral GLP-1 drug in the pipeline, orforglipron, which is being investigated as a treatment for both type 2 diabetes and obesity
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