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If the mouse figure of 3.5% oral bioavailability holds in humans, 100 mg swallowed delivers roughly 3.5 mg systemically, which is why 100 mg oral and 5 mg subcutaneous end up as the two standard protocols

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Your nerves also require vitamin B12 to function properly

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Where results are borderline, measurement of methylmalonic acid (MMA) or holotranscobalamin (active B12) may help clarify the picture, as recommended in NICE CKS guidance on B12 and folate deficiency anaemia