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The most common effects menopausal women on GLP-1s notice in the first few weeks can include: Nausea Bloating Fatigue Constipation Reduced energy These typically happen because appetite signals begin to shift and digestion slows

Also, though the improvements in desire were statistically significant, some experts pointed out that overall, the impact was mild

The changes were similar to what was observed in the cagrilintide and semaglutide groups

However, when the level of long-chain acylcarnitines (LCACs) is abnormally elevated, not only is it a signal of mitochondrial dysfunction but its high concentration can also aggravate mitochondrial damage and further deteriorate mitochondrial function [20, 21]

Evans et al., 2000